For many people, ۲ӰԺ oil is a natural alternative to conventional treatments for a wide range of health concerns. Short for cannabidiol, ۲ӰԺ is one of the two best-researched cannabinoids in the cannabis plant.
More abundant in hemp than in marijuana, ۲ӰԺ works by interacting with the human endocannabinoid system — the prime neurochemical network that maintains the balance between vital biological processes.
But how exactly does ۲ӰԺ work for migraines? Where should you look for the best ۲ӰԺ oil if you want to manage your migraine headaches?
This article covers the use of ۲ӰԺ in the treatment of migraines and highlights the most reliable brands in 2022.
Let’s start with an industry overview.
Best ۲ӰԺ Oil for Migraines: Recommended Brands for 2022
Finding quality ۲ӰԺ products in an unregulated market can be challenging, especially when it comes to the ۲ӰԺ industry, which is very loosely regulated, to say the least.
There are many factors that come into play, such as the source of hemp, extraction methods, and third-party lab reports — all of which determine the quality of ۲ӰԺ oil.
If you don’t want to spend hours researching your potential supplier, reading reviews, and checking the above information, we’ve already done the job for you. Here’s our list of the top 5 brands we recommend when it comes to using ۲ӰԺ for migraines.
1. (Best Migraine Reliever)
Product Details
| Potency | 250 mg – 2500 mg |
| Available Flavors | Natural, Berry, Mint, Vanilla |
| ۲ӰԺ per serving | 8.3 mg – 83.3 mg |
Why Royal ۲ӰԺ is the Best ۲ӰԺ Oil for Migraines:
While it’s not common for a newcomer to make such big headlines in the industry after being on the market for just 2 years, Royal ۲ӰԺ shows that the premium quality of ingredients is a better way to market your products than fancy buzzwords and seemingly “cutting edge” products.
This California-based brand sells traditional ۲ӰԺ products from craft hemp plants sourced from local growers as well as from farms in Colorado. The guys at Royal ۲ӰԺ offer regular ۲ӰԺ oil drops, soft gel capsules, gummies, and two types of topicals.
The ۲ӰԺ oil is available in potencies from 250 mg to 2500 mg, allowing the user to choose the right concentration of ۲ӰԺ for their migraine symptoms. I’ve tested both the 1000 mg and 2500 mg bottle and they worked fine for even serious headaches that I usually experience when the aura triggers them.
My verdict?
I prefer the 2500 mg option because I know my dosage and this potency helps me save more money on my purchases in the long run. I also don’t need to hold as much oil in my mouth as I would with the 1000 mg bottle.
If you experience milder symptoms or want to use ۲ӰԺ oil for the prevention of migraines, you can try the lower potencies. These are full-spectrum extracts, so you don’t need to use such high doses as with ۲ӰԺ isolate or broad-spectrum extracts.
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2. Gold Bee

Product Details
| Potency | 300 – 1200 mg |
| Available Flavors | Natural, Honey |
| ۲ӰԺ per serving | 10 mg – 40 mg |
About Gold Bee
Our second-best ۲ӰԺ oil for migraines comes from California as well. Gold Bee is a premium company that offers the combined benefits of ۲ӰԺ and honey. The brand’s mission is to destigmatize hemp, which was demonized for the past few decades in the media, and provide the health benefits of cannabidiol with a diverse product lineup.
Gold Bee has partnered with its local farmers and growers from Colorado to make their proprietary blend of ۲ӰԺ-rich strains, resulting in clean and potent extracts that carry the full spectrum of cannabinoids, terpenes, and other beneficial hemp compounds.
In my opinion, this is the best ۲ӰԺ oil for migraine sufferers dealing with mild to moderate symptoms. Gold Bee covers the standard potency range, from 300 to 1200 mg ۲ӰԺ, so if your daily dose doesn’t exceed 30 mg, you’re getting the best value for your money considering the quality of ingredients used in Gold Bee extracts.
All of Gold Bee products are made with organic hemp, extracted with supercritical CO2, and third-party tested for their potency and potential contaminants. I’ve been taking this ۲ӰԺ oil (1200 mg) for 30 days and noticed decent improvements in my morning headaches before they were able to knock me off for the rest of the day.
I definitely recommend if you want to use ۲ӰԺ for preventive purposes.
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3. ۲ӰԺPure

Product Details
| Potency | 100 – 1000 mg |
| Available Flavors | None |
| ۲ӰԺ per serving | 3.3 – 33 mg/mL |
About ۲ӰԺPure ۲ӰԺ Oil
۲ӰԺPure is one of the most transparent companies I’ve ever come across. This brand goes above and beyond to share as much information about its activity as possible.
Although the potency of ۲ӰԺPure products isn’t as high as Royal ۲ӰԺ, these extracts clearly deserve the third place in this list of the best ۲ӰԺ oil for migraines. That’s because of how effective they are at low doses.
There are months when my migraines are more manageable thanks to ۲ӰԺ, so when I don’t feel the need to use my high-potency ۲ӰԺ oils, I always keep a bottle of the 600 mg ۲ӰԺ oil from ۲ӰԺPure. It works much better for my migraines than some allegedly full-spectrum products from other popular brands.
۲ӰԺPure uses organic hemp plants as its source of ۲ӰԺ. These plants are further processed with CO2 under high pressure and low temperatures to preserve the original phytochemical profile of the source plant. The company provides reports from a third-party laboratory, where its products are tested for potency and purity.
If you decide that ۲ӰԺPure products don’t bring satisfying results, you can return your order within 90 days after your purchase for a full refund.
I didn’t return mine because I was 100% satisfied, although the price could be a bit lower for that potency range.
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4. Hemp Bombs

Product Details
| Potency | 125 – 4000 mg |
| Available Flavors | Natural, Acai Berry, Orange Creamsicle, Peppermint, Watermelon |
| ۲ӰԺ per serving | 4 – 133 mg/mL |
About Hemp Bombs
Hemp Bombs is my favorite company when it comes to ۲ӰԺ isolate. The company offers 99% pure ۲ӰԺ oil that has no other cannabinoids (including THC) and terpenes, providing the highest potency per serving of all the brands from this ranking.
Although I prefer full-spectrum products, Hemp Bombs comes in handy when my migraines kick in in the evening and I can’t fall asleep. Extremely high doses of ۲ӰԺ are known for inducing sedation, so not only does this oil help with my headaches, but it also acts on my sleep cycle in a positive way.
Hemp Bombs extracts are sold in a few different potencies, from 300 mg to a whopping 4000 mg of ۲ӰԺ per bottle. While the company’s strongest oils are overkill for most people, those suffering from severe headaches — especially in the evening — consider them the best ۲ӰԺ oils for migraines.
Hemp Bombs also sells broad-spectrum ۲ӰԺ oil if you want to benefit from other cannabinoids and terpenes but without any THC in your product.
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5. ۲ӰԺistillery

| Potency | 250 – 5000 mg |
| Available Flavors | None |
| Potency | 8.3 – 166 mg/mL |
About ۲ӰԺistillery
۲ӰԺistillery is a daughter brand of Balanced Health Botanicals, and one of the largest ۲ӰԺ suppliers in North America. Throughout the years, ۲ӰԺistillery reformulated its ۲ӰԺ oils and expanded its line of ۲ӰԺ extracts with broad-spectrum products labeled as “pure ۲ӰԺ oil.” The pure oil version contains ۲ӰԺ and other cannabinoids from hemp but without traces of THC. The psychoactive cannabinoid has been removed after initial extraction.
The ۲ӰԺistillery ۲ӰԺ oil is available in five different strengths, from 250 mg to 5000 mg of total ۲ӰԺ. This covers the entire potency range for ۲ӰԺ extracts. While the company’s products aren’t made from organic hemp, the quality of their ۲ӰԺ remains on a decent level, especially when you consider the price of this ۲ӰԺ oil.
My thoughts on this brand?
۲ӰԺistillery is a great company if you want a high-quality product without breaking the bank. My preferred potency with this brand is the 1000 mg; it did an exceptional job for my headaches from seasonal allergies. And believe me, there’s nothing worse than migraines crossed with headaches from hay fever.
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A Brief Overview of Migraines
Migraines are defined as an intense pain throbbing to a certain area in the head. This pain is nothing compared to regular headaches; migraine attacks can be debilitating and often involve symptoms like nausea, vomiting, as well as sensitivity to light and sound.
The Migraine Research Foundation estimates that migraines are the 3rd-most prevalent disease worldwide — affecting 12% of the population.
Interestingly, women are 3 times more likely to suffer from migraines than men.
Migraines can be triggered by:
- Stress
- Sleep disturbances
- Smells
- Bright lights
- Allergies
- Hormonal changes
The triggers will vary between individuals, as will the symptoms. Some people with chronic migraines can actually predict their headaches by seeing an aura that appears shortly before the attack. Again, the aura differs from one person to another. Some people see zig-zag lines or experience temporary loss of vision, while others will have brief visual hallucinations or earaches before or after the migraine kicks in.
Migraines also last longer than typical headaches. A migraine attack can actually last between 4 to 72 hours. On top of that, even the simplest activities can intensify your symptoms. Painkillers are a common choice among many migraine sufferers but they come with side effects such as addiction or vomiting.
Hence the sudden popularity of ۲ӰԺ oil among migraine sufferers.
Does ۲ӰԺ Oil Work For Migraines And Headaches?
Before becoming illegal, cannabis has been used for centuries as a treatment for headaches. Today, we can understand the reason why ۲ӰԺ and other cannabinoids are so effective in the .
۲ӰԺ interacts with the body’s endocannabinoid system (ECS).
The ECS is the prime regulatory network that controls biological processes like pain transmission, appetite, sleep cycles, memory, emotional stability, fertility, and immune response.
The body also has cannabinoid receptors that interact with compounds such as ۲ӰԺ.
Research shows that migraine sufferers have lower than average levels of Anandamide. Anandamide is an endocannabinoid whose deficiency in the ECS has been linked to migraine attacks. A study conducted by cannabinoid expert Ethan Russo concludes that using plant-derived cannabinoids can balance those deficiencies and help with a wide range of serious health problems, including chronic migraines.
Benefits of Using ۲ӰԺ Oil for Migraines
Research on the benefits of ۲ӰԺ for migraines is still in its infancy due to the federal status of cannabis. Nevertheless, some laboratories have run studies that suggest ۲ӰԺ may be an effective form of treatment for migraines and other types of chronic pain.
Chronic Migraine and Pain Relief
During the 3rd Congress of the European Academy of Neurology, researchers presented interesting results of their study on the use of . The first phase of their research involved testing 48 patients with chronic migraines who were administered a mix of two compounds. The first extract contained 19% THC while the other had 9% ۲ӰԺ and no THC. The researchers used oral solutions for their study; although doses under 100 mg didn’t provide any relief, the 200 mg doses lowered the pain by 55%.
In the second stage of the study, the researchers analyzed people with migraines and cluster headaches. 79 people received daily doses of 200 mg THC-۲ӰԺ solution and were compared to the group of patients treated with Amitriptyline, a tricyclic antidepressant in a 25 mg dose. The treatment lasted for 4 months.
The mix of THC and ۲ӰԺ reduced migraine headaches by up to 41% while amitriptyline showed a 40% reduction in the symptoms. The cannabinoid blend also reduced the intensity of that pain by 43.5%.
۲ӰԺ as an Alternative Treatment to Opioids for Chronic Pain
Studies also indicate that ۲ӰԺ and ۲ӰԺ-THC strains of cannabis can help patients suffering from chronic pain and want to switch from opioid treatments. According to a study published in The Journal of Headache and Pain in 2018, there’s a clear link between the use of ۲ӰԺ for migraine relief and the reduced use of opioids.
Legality: Is ۲ӰԺ Legal?

۲ӰԺ can be extracted from hemp or marijuana, which is why the legal status of ۲ӰԺ is still a controversial topic.
Marijuana remains illegal on the federal level, although some parts of the US have legalized its recreational use and most states have medical programs for marijuana patients.
On the other hand, hemp-derived ۲ӰԺ has been legal since the amendment of the 2018 Agriculture Improvement Act known as the “Farm Bill.” ۲ӰԺ oil from hemp is widely available over the counter throughout the United States, both locally and online.
How to Use ۲ӰԺ Oil for Migraines?
۲ӰԺ oil can be administered through:
- Inhalation
- Sublingual use
- Oral ingestion
- Topical application
Vaping ۲ӰԺ has a difficult learning curve, so beginners may want to start with other forms of consumption. You can:
- Put a few drops of ۲ӰԺ under your tongue
- Take ۲ӰԺ capsules
- Eat or drink ۲ӰԺ-infused treats
That being said, vaping is the most bioavailable method for severe migraines because the compound is delivered to your brain quicker.
Potential Risks: Are there any side effects of ۲ӰԺ Oil?
۲ӰԺ oil has a very short list of side effects, most of them are mild. However, you may experience:
- Sedation
- Lightheadedness
- Changes in appetite
- Upset stomach
The side effects of ۲ӰԺ depending on the consumption method. For example, vaping ۲ӰԺ liquid can trigger lung irritation, resulting in wheezing and breathing difficulties. You should also remember about the potential interaction between ۲ӰԺ and prescription drugs. If you use any prescription medication for your headaches, consult your doctor before you order ۲ӰԺ oil.
Final Thoughts on Using ۲ӰԺ for Migraines
Hopes are high when it comes to using ۲ӰԺ oil for migraines and pain relief in general. Although more research is needed to prove its efficacy in the long run, current findings and reports from patients indicate that we may be one step closer to finding an effective and safe alternative to conventional migraine treatment options.
Do you use ۲ӰԺ for migraines? Does ۲ӰԺ oil help with your symptoms?