Anxiety is a normal reaction that humans have developed over the course of evolution to protect themselves against other predators. There’s nothing wrong with feeling anxious in certain situations — this means your body has a proper reaction to real dangers.
However, if you regularly experience the “fight or flight response” — even without life-threatening events — there’s a chance that you’ll develop some form of anxiety disorder.
Which isn’t difficult to achieve if you look at modern times and how much pressure they’re putting on your shoulders.
Plants and herbs have been used for their relaxing effects for centuries, but cannabis plants seem outstandingly helpful in reducing the symptoms of anxiety and other issues associated with chronic stress.
That’s why thousands of people are now using ۲ӰԺ oil to manage their symptoms.
But how to find a high-quality ۲ӰԺ oil if you’ve never bought one before? How do you find a trusted supplier when there are so many companies on the market?
Best ۲ӰԺ Oil Products for Anxiety and Depression in 2022
In this guide, we share our recommendations for the best ۲ӰԺ on the market today and everything you need to know about the effects of ۲ӰԺ on anxiety disorders.
After meticulous research, we’ve selected the top 5 brands so you don’t have to spend hours reading reviews, comparing prices, and trying every ۲ӰԺ oil out there.
Check out the list below.
1. (Best Overall)
Royal ۲ӰԺ is a premium brand from California that offers the best value in its price range. The company’s products are top shelf when you consider the wide potency range of its ۲ӰԺ oil, the way Royal ۲ӰԺ makes its products, and the effort it puts into testing its ۲ӰԺ selection.
Royal ۲ӰԺ oil is available in four potency options: 250 mg, 500 mg, 1000 mg, and 2500 mg. This makes the company suitable for every type of ۲ӰԺ consumer out there.
This is a full-spectrum ۲ӰԺ oil, so you’re getting the whole range of non-psychoactive cannabinoids, terpenes, flavonoids, and only trace amounts of THC (less than 0.3%).
Royal ۲ӰԺ uses carbon dioxide in its supercritical form to pull the ۲ӰԺ from its organic hemp plants. This method involves running CO2 through the plant material under different pressure levels and temperatures, changing its state from liquid to gas. From there, it dissipates and leaves behind a cold, viscous liquid extract.
All Royal ۲ӰԺ products are extensively tested in terms of purity and potency in independent laboratories to ensure their quality. The company also has free shipping for all customers and accepts full refunds for those who aren’t satisfied with the product.
2. (Best Organic)

Gold Bee was founded by a group of hemp activists who had previously worked in the superfood industry. One thing you can be sure about this brand is that it knows the meaning of the word “organic” more than any ۲ӰԺ company out there. From locally sourced hemp to solventless extraction and rigorous testing practices — everything about this company is premium. Except for the pricing. Gold Bee makes some of the most affordable ۲ӰԺ products on the market in their quality grade.
Gold Bee offers full-spectrum ۲ӰԺ oils in three potency options, including 300 mg, 600 mg, and 1200 mg. This is a great potency range for both beginners and experienced users whose ۲ӰԺ dosage doesn’t exceed 40 mg daily.
On top of the premium quality of ingredients, this company has some of the best-tasting ۲ӰԺ oils we’ve tried so far. You can choose between Kiwi and Honey flavors; we strongly recommend the signature one (honey) — it will change the way you look at flavored ۲ӰԺ oils.
Gold Bee also sells ۲ӰԺ capsules and gummies for those who are looking for a more convenient way to take ۲ӰԺ throughout the day.
3. ۲ӰԺistillery (Runner Up)

It’s been 6 years since ۲ӰԺistillery made its debut, so it pleases us to see that the company has managed to uphold its reputation through that time. The company has a broad selection of ۲ӰԺ oils, available as full-spectrum or pure oil (zero THC).
There are five different strengths to choose from – 250 mg to 5000 mg of total ۲ӰԺ. Moreover, each option is highly affordable compared to competitor brands. That’s because ۲ӰԺistillery’s mission is to provide education and access to ۲ӰԺ products for everyone who needs them. For example, the 250 mg strength costs 0nly $20, which is a great place to start for those who’ve never taken ۲ӰԺ oil before. The maximum potency is priced at $240.
Our only concern about ۲ӰԺistillery is how the company sources its hemp. The plants aren’t organic (although non-GMO), but considering the prices of its ۲ӰԺ oil, this is just a minor downside.
These are still the best extracts in this price category.
4. NuLeaf Naturals

NuLeaf Naturals is another seasoned manufacturer, but unlike Royal ۲ӰԺ and ۲ӰԺistillery, it only makes full-spectrum ۲ӰԺ oil drops. And while this isn’t the most impressive product selection out there, the quality of the NuLeaf Naturals ۲ӰԺ oil makes up for the lack of other formats.
The oil comes in different sizes, from 240 mg to 4850. We don’t say “potency” for purpose, as you get the same strength no matter the size, so your choice here boils down to how long you want your ۲ӰԺ oil to stay with you.
Another noteworthy thing about NuLeaf Naturals is that it uses organic hemp for all of its oils. Each batch of product is sent to a certified lab for extensive content analysis to ensure both the potency and purity levels are consistent in every bottle.
5. Charlotte’s Web

Charlotte’s Web is the company to which we owe the ۲ӰԺ craze. It was established by Stanley Brothers, whose cannabis oil helped young girl Charlotte Figi come down from multiple seizures a day to a few seizures a month.
Charlotte’s Web products are certified by the U.S. Hemp Authority, ensuring they meet the highest quality standards.
You can choose from four strengths: 300 mg, 750 mg, and 2850 mg — a potency range similar to what Royal ۲ӰԺ offers. Each option is available in 30 ml and 100 ml bottles.
Unlike many other brands, Charlotte’s Web uses olive oil extraction instead of CO2, which is why its oils are slightly greener in color and have a more viscous consistency.
6. ۲ӰԺPure

It seems you can’t have a list of the best ۲ӰԺ oils on the market without mentioning ۲ӰԺPure.
۲ӰԺPure is known for making premium-quality ۲ӰԺ products as well as unmatched transparency. The company uses supercritical CO2 extraction and thoroughly filters the final extract from the plant material, so it has a nice amber color. Unfortunately, with a surprisingly tart taste.
۲ӰԺPure oils are available in three different concentrations: 100 mg, 300 mg, and 600 mg. The lowest strength provides only 3.3 mg of ۲ӰԺ per serving, but considering that these are full-spectrum oils, you can achieve a lower effective dose because you get the synergistic effects from the cannabinoids and terpenes.
We would call ۲ӰԺPure the best company for beginners.
What Is Anxiety?
Anxiety is a normal human response to stress triggers. Also known as the “fight-or-flight” response, it describes a range of physical reactions, such as sweating, increased heartbeat, sensitivity to environmental triggers, and a rush of adrenaline.
When anxiety gets proportionally high compared to the seriousness of the trigger, it may become an anxiety disorder.
Once there, the anxiety worsens to the point when an individual’s mental health is deeply affected, including daily functioning.
Types of Anxiety Disorders
There are four common types of anxiety disorders:
- Generalized Anxiety Disorder: it happens when people get chronically anxious for no specific reason. It’s also the most common anxiety disorder.
- Phobias: phobias refer to the overwhelming fear of a specific object or situation. They often block people from engaging in everyday situations due to that fear.
- Panic Disorder: panic attacks happen randomly and are followed by symptoms like shaking, dizziness, confusion, nausea, tremors, and breathing difficulties. They can last anywhere between several minutes and an hour.
What Are the Symptoms of Anxiety?
Below we share the full list of symptoms that can help you determine whether you’re suffering from an anxiety disorder:
- Dizziness & migraines
- Dry mouth
- Emotional outbursts
- Feelings of insecurity
- Heart palpitations
- Muscle tension
- Panic
- Sleep problems
- Somatic complaints
What Can Cause Anxiety?
Anxiety can have different roots. There are usually a few factors involved, namely:
Genetic Burden
If your family member has been diagnosed with an anxiety disorder, there’s a risk that you may develop the same condition over time.
Brain Damage and Changes in Brain Structure
Surviving a traumatic event or genetic changes in the brain may cause an overreaction to potentially harmless triggers. Scientists believe that the majority of anxiety disorders stem from impaired communication between nerve cells.
Environment
Certain elements of your surroundings can worsen your disorder. This may be constant stress at school, work, or even at home. Sometimes, things like the loss of someone close or a bad financial situation can also elevate anxiety.
When you don’t get enough sleep, it can also contribute to an anxiety disorder.
Just as staying in high altitude areas, where the brain can’t access sufficient oxygen levels.
Medical Conditions
Sometimes, anxiety can be collateral damage from another health condition, health supplements or prescription meds you’re taking, or any other disease that can either affect the structure of your brain or cause you to experience severe stress.
Can ۲ӰԺ Oil Help With Anxiety?

Proper anxiety management can be a real challenge.
First of all, and their cost is continuously increasing. If you want anti-anxiety meds prescribed to you, you’ll have to pay for them by yourself before the insurance covers some part of it.
Moreover, many prescription drugs used to manage anxiety can cause a range of negative side-effects. If you try to get through the list of adverse reactions on any popular medication, you’ll understand that they may do more harm than good in the long run.
Don’t get us wrong. We’re not trying to convince you to ditch your current treatment. If it works for you and you don’t feel like making a change, that’s totally good. But some people either can’t take medications or their anxiety isn’t severe enough to qualify for the conventional treatment.
That’s why some anxiety sufferers are choosing natural solutions for relief.
۲ӰԺ oil has many health benefits, but can it help with anxiety and depression?
Reports from patients and data from studies suggest that ۲ӰԺ oil may even be a better treatment than pills and shots for anxiety. Compared with conventional treatment, the side effects of ۲ӰԺ oil are nearly nonexistent unless taken in extremely large doses.
۲ӰԺ and Anxiety: How Does ۲ӰԺ Work?
Why are so many people turning to ۲ӰԺ oil as an alternative anxiety treatment?
Because ۲ӰԺ improves the functioning of the body’s endocannabinoid system (ECS); which is a neurochemical network with cannabinoid receptors in every organ of the body. The ECS controls vital functions, such as sleep, mood, memory, cognition, appetite, pain, immune response, and more.
Put simply, the ECS keeps the body in homeostasis — a fancy word for chemical balance.
However, if your neurochemicals suffer from imbalances, it may trigger anxiety.
This stick has two ends. For example, when you suffer from a traumatic event, your receptors and neurons may fall out of balance, and your body will need something to restore it.
This is where ۲ӰԺ may come in handy.
۲ӰԺ and 5-HT1A Receptor
serotonin receptor in the brain, primarily responsible for the way the body absorbs serotonin.
This receptor is also the target of the commonly prescribed anti-anxiety drugs and antidepressants, which have their own name — Selective Serotonin Reuptake Inhibitors (SSRIs).
SSRIs can stop the reuptake of serotonin, increasing the brain’s ability to give more signals to the body, bring back emotional stability, and reduce anxiety. ۲ӰԺ affects 5-HT1A in a similar way.
۲ӰԺ and Hippocampal Neurogenesis
The hippocampus is the area of your brain that regulates a few processes. One of them is the ability to create new neurons — also known as neurogenesis. , improving its functioning.
Patients diagnosed with anxiety disorders often show a smaller hippocampus, so by stimulating the regeneration of neurons with ۲ӰԺ oil, there’s a higher chance of minimizing those fearful behaviors.
۲ӰԺ and GABA
Australian researchers described ۲ӰԺ as a “positive allosteric modulator” of the GABA receptors in the brain.
Being the primary inhibitory neurotransmitter in the human central nervous system, GABA acts as a handbrake for the brain to slow the nervous system down when we get too aroused. The calming and sedating effects of Valium and other benzodiazepines result from their impact on the GABA-A receptor.
By modulating this receptor, and curb anxiety.
۲ӰԺ and Anandamide
Anandamide is the best-researched endocannabinoid (produced inside the body). It has a chemical structure that’s almost identical to THC, the main psychoactive substance in cannabis.
Researchers refer to anandamide as “the bliss molecule” due to its ability to control feelings of euphoria, happiness, and emotional stability — on top of many other processes. in the brain, reducing mood swings and improving reactions to stress triggers.
Studies on ۲ӰԺ Oil and Anxiety
۲ӰԺ oil has been shown as an effective anti-anxiety compound in both animal and human-based studies.
In a on social anxiety, researchers showed that ۲ӰԺ can reduce the symptoms of social anxiety disorder. ۲ӰԺ also improved the way the patients reacted to anxiety.
A on rat models showed that ۲ӰԺ has strong anti-anxiety and antidepressant effects. Although the results came from animals, they gave a promising insight into the management of anxiety in human subjects.
In 2015, published a report where ۲ӰԺ was highlighted as the next potential solution for anxiety disorders and its symptoms.
All of the above studies were conducted using high-quality ۲ӰԺ oil, which brings us to the next section.
What Affects the Quality of ۲ӰԺ Oil?
The FDA in the United States doesn’t regulate ۲ӰԺ oil. Even though it may be safer and more effective in treating anxiety disorders than conventional treatment methods, it’s still classified as a health supplement, not a medication.
Similar to other health supplements, it may be difficult for new buyers to know if they’re buying pure ۲ӰԺ oil that carries the advertised potency.
You could be taking a product full of synthetic additives and with little to no ۲ӰԺ inside, and you wouldn’t even know it because lab-testing is optional for manufacturers.
If you want to minimize the risk of failed purchases, you’ll need to learn how high-quality ۲ӰԺ oils are made.
Hemp Source
Cannabis plants are bioaccumulators, meaning they can absorb anything from their environment. When grown in clean soil and using organic practices, the plants will yield pure and potent extracts.
On the other hand, hemp that was cultivated in polluted soil and with pesticides will give you weak and contaminated oil.
We recommend buying ۲ӰԺ oil from companies that use organic hemp, preferably those grown on American farms in states like Oregon, Colorado, and California.
Extraction Method
Brands employ different extraction methods and ways of processing ۲ӰԺ oil. Choose brands that use supercritical CO2 extraction, as it’s considered the most effective way to obtain ۲ӰԺ — with a low-risk profile.
Alternatively, you can buy alcohol-extracted ۲ӰԺ tinctures. Some companies also use olive oil, but if a brand extracting its products with butane or propane, there’s a high risk of contamination with unpurged solvent residue.
Third-Party Lab Tests
Reputable ۲ӰԺ companies make third-party lab results available on their websites or add them to the product’s package. Laboratory testing ensures that the actual content of your oil matches what’s advertised on its bottle. Lab tests analyze the potency of ۲ӰԺ oil and look for potential contaminants in the test sample.
Third-party reports are solid evidence of its quality.
Where to Buy ۲ӰԺ Oil Near Me: In-store vs. Online
۲ӰԺ oil is widely available both locally and online. If you live anywhere near a cannabis dispensary or head shop, you can see what they have to offer, but most of the time, there will be no fireworks. In-store vendors often don’t have the best products out there, not to mention that they might have been improperly stored before being put on the shelves.
There’s also a chance that when you buy something from a head shop, you’ll probably find it for half the price online.
And this is where we like to buy our ۲ӰԺ products.
Most ۲ӰԺ oil stuff is sold online these days. When buying ۲ӰԺ products online, you have access to every format out there, let alone different potency options, flavors, and bottle sizes. Online vendors also offer loyalty programs for returning customers, as well as seasonal deals and discounts on bulk orders.
On top of that, it’s easier to research a ۲ӰԺ company online. Read the website to learn how the company makes its products — What’s the hemp source? How’s the oil extracted? — check lab reports, and read reviews from other customers.
To wrap it up, leave no stone unturned while verifying your potential supplier.
How to Use ۲ӰԺ Oil for Anxiety?
What’s the best ۲ӰԺ dosage? How much ۲ӰԺ oil should you take?
Frankly, there are no strict guidelines because everyone reacts differently to ۲ӰԺ oil. Factors such as the person’s age, weight, the severity of symptoms, and type of effects can affect your effective dose.
If it’s your first time with ۲ӰԺ, finding the best dosage for your anxiety and depression will require some trial and error.
Here are some tips to minimize the error part:
- Determine your weight and height.
- Assess the severity of your anxiety — use a scale from 1 to 10.
- Start with one drop of ۲ӰԺ oil per day.
- Increase the dosage steadily. You can use 2-drop increments each day for a few weeks and write down how you react to ۲ӰԺ with each dose.
- Be patient. Sometimes, ۲ӰԺ needs to take time to become noticeable. It can take a few days or weeks until you notice the difference.
- Talk to your doctor about taking ۲ӰԺ oil before buying it. This will help you avoid possible drug interactions between ۲ӰԺ and other medications that you may be taking.
- A study on social anxiety suggests 600 mg as an effective dose in relieving this disorder. However, there are also studies where much lower doses have improved the symptoms.
- If you suffer from sleep problems or severe pain, you may need to take higher doses of ۲ӰԺ because it will try to affect these areas of your being while easing anxiety.
For some people, the bitter taste of ۲ӰԺ oil is too much. If you dislike it, too, try other forms of ۲ӰԺ, such as vape oils, capsules, or gummies.
What Are the Side Effects of Using ۲ӰԺ Oil?
According to the World Health Organization, ۲ӰԺ oil is generally safe and poses no threat of addiction.
The side effects of ۲ӰԺ oil include:
- Dry mouth
- Sedation (high doses)
- Diarrhea (from taking too much oil)
- A temporary drop in blood pressure
- Dizziness
Another potential risk of taking ۲ӰԺ oil is the interaction between ۲ӰԺ and prescription drugs. ۲ӰԺ affects them in a similar way to grapefruit juice, so if you’re using any medications, we suggest that you consult your doctor first.
The greatest danger of using ۲ӰԺ oils for anxiety is the fact that the FDA does not regulate it. Without regulation, you’re at risk of buying a product with synthetic cannabinoids or/and toxic additives in your oil without even knowing it.
Final Thoughts on Using ۲ӰԺ Oil for Anxiety
Dealing with anxiety can be easier with high-quality ۲ӰԺ oil. With more studies conducted on the effects of ۲ӰԺ on a person’s mental health, it’s no wonder that people are choosing ۲ӰԺ as their next aid.
If you’re planning to , make sure it comes from a trusted company that can prove the quality of its products with third-party lab reports and plenty of positive reviews.
۲ӰԺ oil can also help you improve other areas of your well-being, such as sleep cycle, glucose levels, and blood pressure.
It’s a great product if you want to keep yourself in optimal health.
We hope you’ve enjoyed this guide and that you’ll find it useful for your next purchase!